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Literature summary for 2.3.1.28 extracted from

  • Murray, I.A.; Martinez-Suarez, J.V.; Close, T.J.; Shaw, W.V.
    Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenzae, which are sensitive to inhibition by thiol-reactive reagents (1990), Biochem. J., 272, 505-510.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
4,4'-dithiodipyridine
-
 Escherichia coli
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Escherichia coli
methyl methanethiolsulfonate
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0103
-
 chloramphenicol
-
 Escherichia coli
0.065
-
 acetyl-CoA
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 CATII is encoded by the IncW transmissible plasmid pSA
-
Haemophilus influenzae
-
 CATII
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + chloramphenicol
-
 Haemophilus influenzae CoA + chloramphenicol 3-acetate
-
 ?
acetyl-CoA + chloramphenicol
-
 Escherichia coli CoA + chloramphenicol 3-acetate
-
 ?

Synonyms

Synonyms Comment Organism
CAT II enzyme encoded by the incW transmissible plasmid Escherichia coli
CAT II enzyme encoded by the incW transmissible plasmid Haemophilus influenzae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Escherichia coli