Literature summary for 2.3.1.279 extracted from

Touchette, M.H.; Holsclaw, C.M.; Previti, M.L.; Solomon, V.C.; Leary, J.A.; Bertozzi, C.R.; Seeliger, J.C.
The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis (2015), J. Bacteriol., 197, 201-210 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose	Mycobacterium tuberculosis	the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains	a 2-(long-chain-fatty acyl)-trehalose + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WIK5	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose	the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains	Mycobacterium tuberculosis	a 2-(long-chain-fatty acyl)-trehalose + CoA	-	?
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose	the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase)	Mycobacterium tuberculosis	a 2-(long-chain-fatty acyl)-trehalose + CoA	-	?

Synonyms

Synonyms	Comment	Organism
papA3	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)