Literature summary for 2.3.1.264 extracted from

Saum, R.; Mingote, A.; Santos, H.; Mueller, V.
A novel limb in the osmoregulatory network of Methanosarcina mazei Goe1: N(epsilon)-acetyl-beta-lysine can be substituted by glutamate and alanine (2009), Environ. Microbiol., 11, 1056-1065.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + (3S)-3,6-diaminohexanoate	Methanosarcina mazei	-	CoA + (3S)-6-acetamido-3-aminohexanoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Methanosarcina mazei	Q8PYC8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + (3S)-3,6-diaminohexanoate	-	Methanosarcina mazei	CoA + (3S)-6-acetamido-3-aminohexanoate	-	?

General Information

General Information	Comment	Organism
physiological function	deletion of the genes encoding lysine-2,3-aminomutase (ablA) and beta-lysine acetyltransferase (ablB) abolishes the production of N6-acetyl-beta-lysine. The mutant grows well at low and intermediate salinities. Growth at 800 mM NaCl is only slowed down but not impaired. The mutant displays an increased glutamate pool and in addition, alanine is produced up to 0.36 micromol per mg protein. The cellular alanine concentration increases with the salinity of the medium and decreases in the presence of glycine betaine in the medium	Methanosarcina mazei

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Release 2023.1 (January 2023)