Protein Variants | Comment | Organism |
---|---|---|
additional information | development of a competitive in situ labeling strategy using an electrophilic activity-based probe and target protein expressing Escherichia coli cells | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1-aminonaphthalen-2-yl)-2-chloroethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
1-(2-aminophenyl)-2-chloroethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
1-(7-amino-2,3-dihydro-1,4-benzodioxin-6-yl)-2-chloroethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
2-bromo-1-(pyridin-2-yl)ethan-1-one | slight inhibition | Pseudomonas aeruginosa | |
2-chloro-1-(1H-indol-7-yl)ethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
2-chloro-1-(2,4-difluorophenyl)ethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
2-chloro-1-phenylethan-1-one | strong inhibition | Pseudomonas aeruginosa | |
2-chloro-N-(3-chloro-2-methylphenyl)acetamide | strong inhibition | Pseudomonas aeruginosa | |
2-chloro-N-(4-methylphenyl)acetamide | - |
Pseudomonas aeruginosa | |
3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide | - |
Pseudomonas aeruginosa | |
3-chlorobicyclo[2.2.1]heptan-2-one | slight inhibition | Pseudomonas aeruginosa | |
additional information | inhibitor development targeting enzyme PqsD, development of a competitive in situ labeling strategy using an electrophilic activity-based probe and target protein expressing Escherichia coli cells | Pseudomonas aeruginosa | |
N-(butoxymethyl)-2-chloro-N-(2,6-diethylphenyl)acetamide | - |
Pseudomonas aeruginosa | |
tert-butyl chloroacetate | - |
Pseudomonas aeruginosa | |
[4-(2-chloropropanoyl)phenyl]acetic acid | slight inhibition | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | P20582 | - |
- |
Pseudomonas aeruginosa 1C | P20582 | - |
- |
Pseudomonas aeruginosa ATCC 15692 | P20582 | - |
- |
Pseudomonas aeruginosa CIP 104116 | P20582 | - |
- |
Pseudomonas aeruginosa DSM 22644 | P20582 | - |
- |
Pseudomonas aeruginosa JCM 14847 | P20582 | - |
- |
Pseudomonas aeruginosa LMG 12228 | P20582 | - |
- |
Pseudomonas aeruginosa PRS 101 | P20582 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa ATCC 15692 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa 1C | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa PRS 101 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa DSM 22644 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa CIP 104116 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa LMG 12228 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? | |
anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa JCM 14847 | 2-aminobenzoylacetyl-CoA + CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2-heptyl-4(1H)-quinolone synthase | UniProt | Pseudomonas aeruginosa |
PqsD | - |
Pseudomonas aeruginosa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pseudomonas aeruginosa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 1-(1-aminonaphthalen-2-yl)-2-chloroethan-1-one | |
0.0013 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 2-chloro-1-(2,4-difluorophenyl)ethan-1-one | |
0.0018 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 2-chloro-1-phenylethan-1-one | |
0.0019 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 1-(2-aminophenyl)-2-chloroethan-1-one | |
0.0021 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 2-chloro-N-(3-chloro-2-methylphenyl)acetamide | |
0.0022 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 1-(7-amino-2,3-dihydro-1,4-benzodioxin-6-yl)-2-chloroethan-1-one | |
0.0025 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 2-chloro-1-(1H-indol-7-yl)ethan-1-one | |
0.155 | - |
pH not specified in the publication, 37°C | Pseudomonas aeruginosa | 2-chloro-N-(4-methylphenyl)acetamide |