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Literature summary for 2.3.1.262 extracted from

  • Storz, M.P.; Maurer, C.K.; Zimmer, C.; Wagner, N.; Brengel, C.; de Jong, J.C.; Lucas, S.; Müsken, M.; Häussler, S.; Steinbach, A.; Hartmann, R.W.
    Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors (2012), J. Am. Chem. Soc., 134, 16143-16146.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2-nitrophenyl)(phenyl)methanol at a concentration of 250 microM, both the 2-heptyl-4-hydroxyquinoline and Pseudomonas quinolone signal levels are strongly reduced by 77 and 42%, respectively, in Pseudomonas aeruginosa PA14 cultures. The 2,4-dihydroxyquinoline level increases in the presence of the compound. Addition of the compound to a 24 h old biofilm reduces the biovolume of the biofilm by 38% within a 24 h incubation period Pseudomonas aeruginosa
N-[4-hydroxy-4-(2-nitrophenyl)butyl]acetamide
-
 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0032
-
 pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa (2-nitrophenyl)(phenyl)methanol
0.0043
-
 pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa N-[4-hydroxy-4-(2-nitrophenyl)butyl]acetamide