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Literature summary for 2.3.1.26 extracted from

  • Jin, Y.; Rho, M.; Gajulapati, K.; Jung, H.; Boovanahalli, S.; Lee, J.; Song, G.; Choi, J.; Kim, Y.; Lee, K.; Choi, Y.
    Synthesis of a novel series of imidazo[1,2-alpha]pyridines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors (2009), Bull. Korean Chem. Soc., 30, 1297-1304.
No PubMed abstract available
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Inhibitors

Inhibitors Comment Organism Structure
naphthalene-1-carboxylic acid [3-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-amide 48% inhibition at 0.025 mg/ml Homo sapiens
naphthalene-2-carboxylic acid (3-[6-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridin-2-yl]-phenyl)-amide 23.6% inhibition at 0.025 mg/ml Homo sapiens
naphthalene-2-carboxylic acid [3-(6-bromo-imidazo[1,2-a]pyridin-2-yl)-phenyl]-amide 56% inhibition at 0.025 mg/ml Homo sapiens
naphthalene-2-carboxylic acid [3-(6-naphtalen-2-yl-imidazo-[1,2-a]pyridin-2-yl)-phenyl]-amide 7.1% inhibition at 0.025 mg/ml Homo sapiens
[4-(2-(3-[(naphthalene-2-carbonyl)-amino]-phenyl)-imidazo[1,2-a]pyridin-6-yl)-phenoxy]-acetic acid 15% inhibition at 0.025 mg/ml Homo sapiens
[4-(2-(3-[(naphthalene-2-carbonyl)-amino]-phenyl)-imidazo[1,2-a]pyridin-6-yl)-phenoxy]-acetic acid ethyl ester 8.7% inhibition at 0.025 mg/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-