Literature summary for 2.3.1.26 extracted from

Asano, S.; Ban, H.; Kino, K.; Ioriya, K.; Muraoka, M.
Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents (2009), Bioorg. Med. Chem., 17, 4636-4646.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-({1-[2-(3-hydroxypropoxy)phenyl]-4-(3-methoxyphenyl)piperidin-4-yl}methyl)urea	-	Rattus norvegicus
1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-{[1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]methyl}urea	-	Rattus norvegicus
SMP-797	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Rattus norvegicus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000018	-	pH 7.4	Rattus norvegicus	1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-({1-[2-(3-hydroxypropoxy)phenyl]-4-(3-methoxyphenyl)piperidin-4-yl}methyl)urea
0.000031	-	-	Rattus norvegicus	SMP-797
0.000032	-	pH 7.4	Rattus norvegicus	1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-{[1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]methyl}urea

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Release 2023.1 (January 2023)