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Literature summary for 2.3.1.26 extracted from

  • Freeman, N.E.; Rusinol, A.E.; Linton, M.; Hachey, D.L.; Fazio, S.; Sinensky, M.S.; Thewke, D.
    Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages (2005), J. Lipid Res., 46, 1933-1943.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage loss of ACAT activity in macrophages, either by pharmacological inhibition or by genetic knockout of ACAT-1, results in reduced induction of apoptosis in response to 7-ketocholesterol or oxidized low density lipoproteins. The apoptotic signal generated in macrophages by ACAT may be an arachidonyl oxysterol Mus musculus
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