Literature summary for 2.3.1.26 extracted from

Zhang, Y.; Yu, C.; Liu, J.; Spencer, T.A.; Chang, C.C.; Chang, T.Y.
Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1 (2003), J. Biol. Chem., 278, 11642-11647.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cholesterol	significant activation of reaction with 7-ketocholesterol as substrate, decrease in Hill coefficient from 3.0 without cholesterol to 1.1 with cholesterol	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform ACAT1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	very poor substrates: 7-ketocholesterol, 7beta-hydroxycholesterol, 5beta,6beta-epoxycholesterol, 24(S),25-epoxycholesterol	Homo sapiens	?	-	?
oleoyl-CoA + 5alpha,6alpha-epoxycholesterol	activity comparable to cholesterol	Homo sapiens	CoA + 5alpha,6alpha-epoxycholesteryl oleate	-	?
oleoyl-CoA + 7alpha-hydroxycholesterol	activity comparable to cholesterol	Homo sapiens	CoA + 7alpha-hydroxycholesteryl oleate	-	?
oleoyl-CoA + cholesterol	-	Homo sapiens	CoA + cholesteryl oleate	-	?

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Release 2023.1 (January 2023)