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Literature summary for 2.3.1.26 extracted from
- In vitro regulation of bovine adrenal cortical acyl-CoA: cholesterol acyltransferase and comparison with the rat liver enzyme (1983), Biochim. Biophys. Acta, 753, 422-429.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 25-hydroxycholesterol | activates | Rattus norvegicus |  |
| 25-hydroxycholesterol | not stimulatory | Bos taurus | |
| cholesterol | exogenous, not stimulatory | Bos taurus | |
| cholesterol | exogenous, in liposomes or in organic solvent, stimulates | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MgATP2- | inhibition of activity | Bos taurus | |
| MgATP2- | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulates | Bos taurus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | stimulates | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| adrenal gland | - |
Bos taurus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000089 | - |
microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2 + 0.005 mM cAMP + 0.005 mg protein kinase | Bos taurus |
| 0.000093 | - |
microsomes + 5 mM ATP | Bos taurus |
| 0.000099 | - |
microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2 | Bos taurus |
| 0.000117 | - |
control microsomes | Bos taurus |
| 0.000126 | - |
microsomes + 5 mM MgCl2 + 50 mM NaF | Bos taurus |
| 0.000132 | - |
microsomes + 50 mM NaF | Bos taurus |
| 0.000169 | - |
microsomes + 5 mM MgCl2 | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesterol ester | - |
? | |
| acyl-CoA + cholesterol | - |
Bos taurus | CoA + cholesterol ester | - |
? | |
| palmitoyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesteryl palmitate | - |
? | |
| palmitoyl-CoA + cholesterol | - |
Bos taurus | CoA + cholesteryl palmitate | - |
? | |
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Release 2023.1 (January 2023)
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