Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Acetic anhydride | 2 distinct tissue types with difference in reactivity, the inhibitor appears to modify a histidine residue | Oryctolagus cuniculus | |
diethyl dicarbonate | 2 distinct tissue types with difference in reactivity, DEP-sensitive subtype typified by aortic ACTAT, DEP-resistant subtype typified by liver ACAT, irreversible inhibition, the inhibitor appear to modify a histidine residue | Oryctolagus cuniculus | |
p-mercuribenzoate | 100% inhibition of liver and aortic enzyme at 1 mM | Oryctolagus cuniculus | |
Phenylglyoxal | concentration-dependent inhibition of liver enzyme with 65% inhibition at 5 mM | Oryctolagus cuniculus | |
Tetranitromethane | 100% inhibition of liver and aortic enzyme at 1 mM | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a long-chain acyl-CoA + a sterol = CoA + a long-chain 3-hydroxysterol ester | mechanism, a histidine is implicated in the catalytic mechanism of the enzyme | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Oryctolagus cuniculus | - |
adrenal gland | 1.7fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
aorta | 41fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
brain | 1.6fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
heart | 6fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
intestine | 23fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
kidney | - |
Oryctolagus cuniculus | - |
liver | 27fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
lung | 3fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
additional information | overview: enzyme activity in normal and cholesterol-fed organs, identification of two distinct tissue types of the enzyme | Oryctolagus cuniculus | - |
pancreas | 25fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
spleen | 7fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
stomach | - |
Oryctolagus cuniculus | - |
testis | 1.8fold induction of activity after 60 days of cholesterol feeding | Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
overview: normal and cholesterol-fed organs | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | - |
Oryctolagus cuniculus | CoA + cholesterol ester | - |
? | |
oleoyl-CoA + cholesterol | - |
Oryctolagus cuniculus | CoA + cholesteryl oleate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
diethyl dicarbonate | aortic enzyme | Oryctolagus cuniculus | |
0.5 | - |
Acetic anhydride | less than, aortic enzyme | Oryctolagus cuniculus | |
1.5 | - |
diethyl dicarbonate | liver enzyme | Oryctolagus cuniculus | |
5 | - |
Acetic anhydride | greater than, liver enzyme | Oryctolagus cuniculus |