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Literature summary for 2.3.1.255 extracted from
- HYPK promotes the activity of the Nalpha-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins (2022), Sci. Adv., 8, eabn6153.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q8VZM1 and Q9FKI4 | auxiliary subunit NAA15, Q9FKI4i.e. catalytic subunit NAA10 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AA15 | - |
Arabidopsis thaliana |
| At1g80410 | - |
Arabidopsis thaliana |
| At5g13780 | - |
Arabidopsis thaliana |
| NAA10 | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Huntingtin yeast partner (HYPK) physically interacts with the ribosome-anchoring subunit of NatA and promotes Nalpha-terminal acetylation of diverse NatA substrates. Loss-of-HYPK mutants are remarkably resistant to drought stress and strongly resemble the phenotype of NatA-depleted plants. HYPK impairs plant metabolism and development, predominantly by regulating NatA activity | Arabidopsis thaliana |
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