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Literature summary for 2.3.1.255 extracted from

  • Guzman, U.H.; Aksnes, H.; Ree, R.; Krogh, N.; Jakobsson, M.E.; Jensen, L.J.; Arnesen, T.; Olsen, J.V.
    Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae (2023), Nat. Commun., 14, 4517.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P07347 AND P12945 P07347 i.e. subunit Ard1, P12945 i.e. subunit Nat1
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Synonyms

Synonyms Comment Organism
ARD1
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 Saccharomyces cerevisiae
NAA10 catalytic subunit Saccharomyces cerevisiae
NAA15 auxiliary subunit Saccharomyces cerevisiae
Naa50 auxiliary subunit Saccharomyces cerevisiae
NAT1
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 Saccharomyces cerevisiae
NatA
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function deletion of subunit Naa10 disrupts the NatA complex formation resulting in degradation of subunits Naa15 and Naa50. Some members of the Arg/N-end rule and ubiquitin-fusion degradation pathways UBR1, UFD4, UFD2, NTA1, and TOM1 together with the proteasome and autophagy markers such as ATG1, ATG20, ATG11, and PEP4 are upregulated in the deletion mutant. Cytosolic and mitochondrial ribosomal proteins from the small and large subunit as well as mitochondrial proteins related to the electron transport chain are downregulated. The turnover rate of ribosomal proteins is increased in exponentially growing mutant cells Saccharomyces cerevisiae