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Literature summary for 2.3.1.255 extracted from
- Charting the N-terminal acetylome A comprehensive map of human NatA substrates (2021), Int. J. Mol. Sci., 22, 10692.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P41227 AND Q9BXJ9 | P41227 i.e. catalytic subunit NAA10, Q9BXJ9 i.e. auxiliary subunit NAA15 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAA10 | - |
Homo sapiens |
| NAA15 | - |
Homo sapiens |
| NatA | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | knockdown to near complete depletion of NAA10 and NAA15 expression results in lowered N-terminal acetylation of over 25% out of all putative NatA targets identified, an up to 10fold increase. The knockdown affects translation, lipid metabolism and regulation of cyclin-dependent protein kinase activity. A lowered expression of ribosomal proteins and proteins constituting the eukaryotic 48S preinitiation complex is observed. NatA N-terminal acetylation deficiency may directly impact protein stability of knockdown affected targets | Homo sapiens |
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