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Literature summary for 2.3.1.255 extracted from

  • Ingram, A.K.; Cross, G.A.; Horn, D.
    Genetic manipulation indicates that ARD1 is an essential Nalpha-acetyltransferase in Trypanosoma brucei (2000), Mol. Biochem. Parasitol., 111, 309-317.
    View publication on PubMed
Search for more literature for 2.3.1.255

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27500
-
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an N-terminal-glycyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-glycyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-alanyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-alanyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-cysteinyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-cysteinyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-threonyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-valyl-[protein] Trypanosoma brucei
-
 an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-valyl-[protein] Trypanosoma brucei MiTat 427
-
 an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q9NFL8 catalytic subunit ARD1
-
Trypanosoma brucei MiTat 427 Q9NFL8 catalytic subunit ARD1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an N-terminal-glycyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-glycyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-glycyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-alanyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-alanyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-alanyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-cysteinyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-cysteinyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-cysteinyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-seryl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-threonyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-threonyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-valyl-[protein]
-
 Trypanosoma brucei an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-valyl-[protein]
-
 Trypanosoma brucei MiTat 427 an N-terminal-Nalpha-acetyl-L-valyl-[protein] + CoA
-
 ?

Subunits

Subunits Comment Organism
? x * 27500, subunit ARD1, calculated from amino acid sequence Trypanosoma brucei

Synonyms

Synonyms Comment Organism
ARD1
-
 Trypanosoma brucei
ARD1-NAT1 Nalpha-acetyltransferase
-
 Trypanosoma brucei

General Information

General Information Comment Organism
physiological function ARD1 is essential for viability in mammalian and insect-stage Trypanosoma brucei cells Trypanosoma brucei