Literature summary for 2.3.1.250 extracted from

Galli, L.M.; Zebarjadi, N.; Li, L.; Lingappa, V.R.; Burrus, L.W.
Divergent effects of porcupine and Wntless on WNT1 trafficking, secretion, and signaling (2016), Exp. Cell Res., 347, 171-183 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine	Mus musculus	the enzyme is an essential mediators of Wnt secretion and signaling	CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JJJ7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine	-	Mus musculus	CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine	-	?
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine	the enzyme is an essential mediators of Wnt secretion and signaling	Mus musculus	CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine	-	?

Synonyms

Synonyms	Comment	Organism
PORCN	-	Mus musculus
porcupine	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	porcupine (PORCN) and Wntless (WLS) are essential mediators of Wnt secretion and signaling. PORCN and WLS form a complex. THes compete for binding to WNT1. Overexpression of PORCN promotes palmitoylation of WNT1	Mus musculus

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Release 2023.1 (January 2023)