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Literature summary for 2.3.1.244 extracted from

  • Xie, X.; Meehan, M.J.; Xu, W.; Dorrestein, P.C.; Tang, Y.
    Acyltransferase mediated polyketide release from a fungal megasynthase (2009), J. Am. Chem. Soc., 131, 8388-8389.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Aspergillus terreus Q9Y7D5
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Synonyms

Synonyms Comment Organism
lovastatin diketide synthase
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Aspergillus terreus
LovF
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Aspergillus terreus

General Information

General Information Comment Organism
physiological function enzyme LovF synthesizes the alpha-S-methylbutyrate side chain that is subsequently transferred to monacolin J to yield the cholesterol-lowering natural product lovastatin. The diketide product of LovF is offloaded from the LovF acyl carrier protein domain by the dissociated acyltransferase LovD. LovD primarily interacts with the acyl carrier protein domain of LovF and the protein-protein interactions lead to highly efficient transfer of the diketide product. The catalytic efficiency is enhanced nearly one millionfold when LovF is used as the acyl carrier instead of N-acetylcysteamine Aspergillus terreus