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Literature summary for 2.3.1.241 extracted from

  • Mills, G.; Dumigan, A.; Kidd, T.; Hobley, L.; Bengoechea, J.
    Identification and characterization of two Klebsiella pneumoniae lpxL lipid A late acyltransferases and their role in virulence (2017), Infect. Immun., 85, e00068-17 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.241

Application

Application Comment Organism
drug development LpxL2 might be a candidate target in the development of anti-Klebsiella pneumoniae drugs Klebsiella pneumoniae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae W9B4X1
-
-
Klebsiella pneumoniae W9BFU2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA
-
 Klebsiella pneumoniae dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein]
-
 ?
a tetradecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA
-
 Klebsiella pneumoniae tetradecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein]
-
 ?

Synonyms

Synonyms Comment Organism
LpxL1
-
 Klebsiella pneumoniae
LpxL2
-
 Klebsiella pneumoniae

Expression

Organism Comment Expression
Klebsiella pneumoniae the enzyme (LpxL1) is negatively regulated by the two-component system PhoPQ down

General Information

General Information Comment Organism
malfunction lipid A produced by the lpxL2 mutant lacks the 2-hydroxymyristate, palmitate, and 4-aminoarabinose decorations found in the lipid A synthesized by the wild type. The lack of 2-hydroxymyristate is expected since LpxO modifies the myristate transferred by LpxL2 to the lipid A. The absence of the other two decorations is most likely caused by the downregulation of phoPQ and pmrAB expression Klebsiella pneumoniae
physiological function LpxL2-dependent lipid A acylation protects Klebsiella from polymyxins, mediates resistance to phagocytosis, limits the activation of inflammatory responses by macrophages, and is required for pathogen survival in the wax moth (Galleria mellonella). LpxL2 contribution to virulence is dependent on LpxO-mediated hydroxylation of the LpxL2-transferred myristate Klebsiella pneumoniae