Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q9I7B5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform HtrB1 exclusively mediates the addition of the 2-hydroxylaurate in C-2 position of lipid IVaA, while HtrB2 adds the laurate in C-2' position | Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrB1 | - |
Pseudomonas aeruginosa |
PA0011 | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
physiological function | a HtrB1 deletion mutant shows a decrease in 2-hydroxylaurate content in lipid A and otherwise similar growth characteristics as compared to wuild-type at all growth temperatures. A Htr2 deletion mutant shows a decrease in laurate content in lipid A and a major growth defect at 25°C and minor defects at 37 and 42°C. The htrB2 mutant shows increased susceptibility to both polymyxin B and colistin. HtrB1 and Htrb2 mutants display increased membrane permeability | Pseudomonas aeruginosa |