Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.240 extracted from

  • Hansen, D.A.; Koch, A.A.; Sherman, D.H.
    Substrate controlled divergence in polyketide synthase catalysis (2015), J. Am. Chem. Soc., 137, 3735-3738.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.240

Application

Application Comment Organism
synthesis substrate engineering approaches to control the catalytic cycle of a full polykeitde synthase module harboring multiple domains. Using alternatively activated native hexaketide substrates, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring Streptomyces venezuelae

Organism

Organism UniProt Comment Textmining
Streptomyces venezuelae
-
-
-
Streptomyces venezuelae ATCC 15439
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine
-
 Streptomyces venezuelae ?
-
 ?
(3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine
-
 Streptomyces venezuelae ATCC 15439 ?
-
 ?
additional information by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring Streptomyces venezuelae ?
-
 ?
additional information by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring Streptomyces venezuelae ATCC 15439 ?
-
 ?
N-(2-[[(2R,3S,4S,6R,8E,10R,11R)-11-hydroxy-2,4,6,10-tetramethyl-3-[[(2-nitrophenyl)methoxy]methoxy]-7-oxotridec-8-en-1-yl]sulfanyl]ethyl)acetamide + methylmalonyl N-acetylcysteamine
-
 Streptomyces venezuelae ?
-
 ?

Synonyms

Synonyms Comment Organism
type I polyketide synthase PikAIV
-
 Streptomyces venezuelae

Cofactor

Cofactor Comment Organism Structure
additional information enzyme utilizes an oxidized quinone as co-factor Streptomyces venezuelae