Literature summary for 2.3.1.24 extracted from

Sharma, S.; Ahmed, M.; Akhter, Y.
The revelation of selective sphingolipid pathway inhibition mechanism on fumonisin toxin binding to ceramide synthases in susceptible organisms and survival mechanism in resistant species (2018), Biochimie, 149, 41-50 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular modeling of structure, binding of inhibitor fumonisin B1 and comparison with structure of Saccharomyces cerevisiae enzyme	Trichoderma guizhouense
molecular modeling of structure, binding of inhibitor fumonisin B1 and comparison with structure of Trichoderma guizhouense enzyme	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
fumonisin B1	competitive, a refolding of activation loop during fumonisin binding results in catalytic inhibition	Saccharomyces cerevisiae
fumonisin B1	formation of a stable protein-substrate-inhibitor complex. The three molecules bind at different positions within the conserved active site and during a molecular dynamics simulation run no evident change regarding the substitution of sites with substrates and the inhibitor could be observed	Trichoderma guizhouense

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P38703	-	-
Trichoderma guizhouense	A0A1T3CVR0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-CoA + phytosphingosine	-	Saccharomyces cerevisiae	CoA + N-acylphytosphingosine	-	?
acyl-CoA + phytosphingosine	-	Trichoderma guizhouense	CoA + N-acylphytosphingosine	-	?

Synonyms

Synonyms	Comment	Organism
LAG1	-	Trichoderma guizhouense
LAG1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)