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Literature summary for 2.3.1.238 extracted from

  • Xie, X.; Meehan, M.J.; Xu, W.; Dorrestein, P.C.; Tang, Y.
    Acyltransferase mediated polyketide release from a fungal megasynthase (2009), J. Am. Chem. Soc., 131, 8388-8389.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.238

Protein Variants

Protein Variants Comment Organism
S76A active site mutant, no activity Aspergillus terreus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.039
-
 (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] pH and temperature not specified in the publication Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] Aspergillus terreus the enzyme is involved in lovastatin biosynthesis lovastatin acid + [2-methylbutanoate polyketide synthase]
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus terreus Q9Y7D1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] the enzyme is involved in lovastatin biosynthesis Aspergillus terreus lovastatin acid + [2-methylbutanoate polyketide synthase]
-
 ?
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] the enzyme primarily interacts with the ACP domain of 2-methylbutanoate polyketide synthase (LovF) and the protein-protein interactions leads to highly efficient transfer of the diketide product Aspergillus terreus lovastatin acid + [2-methylbutanoate polyketide synthase]
-
 ?

Synonyms

Synonyms Comment Organism
LovD
-
 Aspergillus terreus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.806
-
 (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] pH and temperature not specified in the publication Aspergillus terreus

General Information

General Information Comment Organism
physiological function the enzyme is involved in lovastatin biosynthesis Aspergillus terreus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
20.7
-
 (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] pH and temperature not specified in the publication Aspergillus terreus