Cloned (Comment) | Organism |
---|---|
expression of tcmN in Escherichia coli | Streptomyces glaucescens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces glaucescens | P16559 | TcmN polyketide cyclase. The multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN) | - |
Purification (Comment) | Organism |
---|---|
TcmN polyketide cyclase | Streptomyces glaucescens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10 malonyl-CoA | TcmN is a bifunctional protein that catalyzes the regiospecific cyclization of the linear decaketide (bound to the multi-domain polyketide synthase) to tetracenomycin F2 and the O-methylation of tetracenomycin D3 to tetracenomycin B3 | Streptomyces glaucescens | tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O | - |
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Synonyms | Comment | Organism |
---|---|---|
TcmN polyketide cyclase | the multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN) | Streptomyces glaucescens |