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Literature summary for 2.3.1.235 extracted from

  • Shen, B.; Hutchinson, C.R.
    Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase (1996), Proc. Natl. Acad. Sci. USA, 93, 6600-6604.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of tcmN in Escherichia coli Streptomyces glaucescens

Organism

Organism UniProt Comment Textmining
Streptomyces glaucescens P16559 TcmN polyketide cyclase. The multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN)
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Purification (Commentary)

Purification (Comment) Organism
TcmN polyketide cyclase Streptomyces glaucescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10 malonyl-CoA TcmN is a bifunctional protein that catalyzes the regiospecific cyclization of the linear decaketide (bound to the multi-domain polyketide synthase) to tetracenomycin F2 and the O-methylation of tetracenomycin D3 to tetracenomycin B3 Streptomyces glaucescens tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
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Synonyms

Synonyms Comment Organism
TcmN polyketide cyclase the multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN) Streptomyces glaucescens