Cloned (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Crystallization (Comment) | Organism |
---|---|
2.9 A crystal structure of isoform Qri7 reveals a simple homodimer arrangement that is supplanted by the heterodimerization of YgjD with protein YeaZ | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P36132 | isoform Kae1 | - |
Saccharomyces cerevisiae | P43122 | isoform Qri7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-threonylcarbamoyladenylate + adenine37 in tRNA | - |
Saccharomyces cerevisiae | AMP + N6-L-threonylcarbamoyladenine37 in tRNA | - |
? | |
L-threonylcarbamoyladenylate + adenine37 in tRNA | - |
Saccharomyces cerevisiae | AMP + N6-L-threonylcarbamoyladenine37 in tRNA | isoform Qri7 and protein Sua5 are sufficient for N6-threonylcarbamoyladenosine biosynthesis in vitro | ? |
Synonyms | Comment | Organism |
---|---|---|
Kae1 | - |
Saccharomyces cerevisiae |
Qri7 | - |
Saccharomyces cerevisiae |
t(6)A synthase | - |
Saccharomyces cerevisiae |
t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform Kae1 is part of a larger macromolecular assembly called KEOPS with Kae1, Bud32, Cgi121, Gon7 and Pcc1 subunits. Kae1 provides a core essential function that other subunits within KEOPS have evolved to support. Isoform Qri7 complements isoform Kae1 function and complements the function of all subunits | Saccharomyces cerevisiae |
physiological function | isoform Qri7 complements isoform Kae1 function and complements the function of all subunits of a larger macromolecular assembly called KEOPS with Kae1, Bud32, Cgi121, Gon7 and Pcc1 subunits, in growth, N6-threonylcarbamoyladenosine biosynthesis and, to a partial degree, telomeremaintenance. Qri7 alone is sufficient for N6-threonylcarbamoyladenosine biosynthesis with protein Sua5 in vitro | Saccharomyces cerevisiae |