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Literature summary for 2.3.1.23 extracted from
- Purification and kinetic properties of lysophosphatidylinositol acyltransferase from bovine heart muscle microsomes and comparison with lysophosphatidylcholine acyltransferase (1989), Arch. Biochem. Biophys., 271, 407-413.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Chloroquine | activation | Bos taurus |  |
| iodoacetate | activation | Bos taurus | |
| thimerosal | i.e. sodium ethylmercurithiosalicylate, activation | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Bos taurus | |
| AMP | - |
Bos taurus | |
| Dibucaine | - |
Bos taurus | |
| additional information | not inhibited by ATP | Bos taurus | |
| procaine | - |
Bos taurus | |
| Tetracaine | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Cibacron blue agarose, DEAE cellulose, Matrex green A, 1-acylglycerophosphoinositol O-acyltransferase | Bos taurus |
| solubilized with CHAPS | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.125 | - |
1-acylglycerophosphoinositol O-acyltransferase | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Bos taurus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol | preferred acyl donor arachidonoyl-CoA, other acyl donors: cis,cis-11,14-eicosadienoyl-CoA, cis-11-eicosaenoyl-CoA, linolenoyl-coA, linoleoyl-CoA, oleoyl-CoA, stearoyl-CoA, palmitoleoyl-CoA, palmitoyl-CoA, dodecanoyl-CoA and decanoyl-coA, no activity with 1-acyl-sn-glycero-3-phosphocholine | Bos taurus | CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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