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Literature summary for 2.3.1.229 extracted from

  • Dong, S.; Nhu-Lam, M.; Nagarajan, R.; Nair, S.
    Structure-guided biochemical analysis of quorum signal synthase specificities (2020), ACS Chem. Biol., 15, 1497-1504.
    View publication on PubMed
Search for more literature for 2.3.1.229

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with CoA and p-coumaroyl S-adenosyl-L-homocysteine, to 1.85 A resolution. The CoA binding pocket is lined with hydrophobic residues, including Ile 28, Tyr29, Trp35, Val106, and Trp147. The indole platform comprises residues Trp146 and Trp147 Rhodopseudomonas palustris

Protein Variants

Protein Variants Comment Organism
Q124A mutant shows increased activity with 4-O-methylcinnamoyl-CoA, yielding about 80% N-(4-O-methylcinnamoyl)-L-homoserine lactone Rhodopseudomonas palustris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
 4-coumaroyl-CoA pH not specified in the publication, temperature not specified in the publication Rhodopseudomonas palustris

Organism

Organism UniProt Comment Textmining
Rhodopseudomonas palustris Q6NCZ6
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-
Rhodopseudomonas palustris ATCC BAA-98 Q6NCZ6
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-coumaroyl-CoA + S-adenosyl-L-methionine
-
 Rhodopseudomonas palustris CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone
-
 ?
4-coumaroyl-CoA + S-adenosyl-L-methionine
-
 Rhodopseudomonas palustris ATCC BAA-98 CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone
-
 ?
4-O-methylcinnamoyl-CoA + S-adenosyl-L-methionine
-
 Rhodopseudomonas palustris CoA + S-methyl-5'-thioadenosine + N-(4-O-methylcinnamoyl)-L-homoserine lactone
-
 ?
4-O-methylcinnamoyl-CoA + S-adenosyl-L-methionine
-
 Rhodopseudomonas palustris ATCC BAA-98 CoA + S-methyl-5'-thioadenosine + N-(4-O-methylcinnamoyl)-L-homoserine lactone
-
 ?

Synonyms

Synonyms Comment Organism
RpaI
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 Rhodopseudomonas palustris