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Literature summary for 2.3.1.228 extracted from

  • Christensen, Q.H.; Brecht, R.M.; Dudekula, D.; Greenberg, E.P.; Nagarajan, R.
    Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases (2014), PLoS ONE, 9, e112464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.228

Inhibitors

Inhibitors Comment Organism Structure
isopentyl-CoA competitive Bradyrhizobium diazoefficiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
 isovaleryl-CoA pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens
0.0079
-
 isopentyl-CoA pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens
0.039
-
 S-adenosyl-L-methionine pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens
0.317
-
 isovaleryl-ACP pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens

Organism

Organism UniProt Comment Textmining
Bradyrhizobium diazoefficiens Q89VI2
-
-
Bradyrhizobium diazoefficiens JCM 1083 Q89VI2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isopentyl-CoA + S-adenosyl-L-methionine
-
 Bradyrhizobium diazoefficiens CoA + S-methyl-5'-thioadenosine + N-isopentyl-L-homoserine lactone
-
 ?
isopentyl-CoA + S-adenosyl-L-methionine
-
 Bradyrhizobium diazoefficiens JCM 1083 CoA + S-methyl-5'-thioadenosine + N-isopentyl-L-homoserine lactone
-
 ?
isovaleryl-ACP + S-adenosyl-L-methionine
-
 Bradyrhizobium diazoefficiens ACP + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
-
 ?
isovaleryl-ACP + S-adenosyl-L-methionine
-
 Bradyrhizobium diazoefficiens JCM 1083 ACP + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
-
 ?
isovaleryl-CoA + S-adenosyl-L-methionine isoform BjaI prefers isovaleryl-CoA as a substrate Bradyrhizobium diazoefficiens CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
-
 ?
isovaleryl-CoA + S-adenosyl-L-methionine isoform BjaI prefers isovaleryl-CoA as a substrate Bradyrhizobium diazoefficiens JCM 1083 CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
-
 ?

Synonyms

Synonyms Comment Organism
BjaI
-
 Bradyrhizobium diazoefficiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
 isovaleryl-ACP pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens
0.021
-
 isovaleryl-CoA pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.021
-
 pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens isopentyl-CoA

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0063
-
 isovaleryl-ACP pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens
3
-
 isovaleryl-CoA pH 7.3, temperature not specified in the publication Bradyrhizobium diazoefficiens