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Literature summary for 2.3.1.225 extracted from

  • Howie, J.; Reilly, L.; Fraser, N.J.; Vlachaki Walker, J.M.; Wypijewski, K.J.; Ashford, M.L.; Calaghan, S.C.; McClafferty, H.; Tian, L.; Shipston, M.J.; Boguslavskyi, A.; Shattock, M.J.; Fuller, W.
    Substrate recognition by the cell surface palmitoyl transferase DHHC5 (2014), Proc. Natl. Acad. Sci. USA, 111, 17534-17539.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.225

Cloned(Commentary)

Cloned (Comment) Organism
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 Mus musculus
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 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VDZ4
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-
Rattus norvegicus Q2THW7
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-

Source Tissue

Source Tissue Comment Organism Textmining
heart isoform DHHC5 is among the most abundantly expressed DHHCs in the heart and localizes to caveolin-enriched cell surface microdomains. DHHC5 coimmunoprecipitates with cardiac protein phospholemman in ventricular myocytes and transiently transfected cells Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + [phospholemman]-L-cysteine
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 Mus musculus [phospholemman]-S-palmitoyl-L-cysteine + CoA isoform DHHC5 palmitoylates cardiac phosphoprotein phospholemman at two juxtamembrane cysteines, C40 and C42. C40 is the principal palmitoylation site ?

Synonyms

Synonyms Comment Organism
DHHC5
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 Mus musculus
DHHC5
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function isoform DHHC5 palmitoylates cardiac phosphoprotein phospholemman at two juxtamembrane cysteines, C40 and C42. Phospholemman interaction with and palmitoylation by DHHC5 is independent of the DHHC5 PSD-95/Discslarge/ZO-1 homology binding motif, but requires an about 120 amino acid region of the DHHC5 intracellular C-tail immediately after the fourth transmembrane domain. Phospholemman mutant C42A but not phospholemman mutant C40A inhibits the cardiac Na pump Mus musculus