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Literature summary for 2.3.1.22 extracted from

  • Mostafa, N.; Bhat, B.G.; Coleman, R.A.
    Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver (1993), Biochim. Biophys. Acta, 1169, 189-195.
    View publication on PubMed
Search for more literature for 2.3.1.22

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin stimulates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,4,6-Trinitrobenzene sulfonic acid
-
 Rattus norvegicus
CaCl2 12.5 mM, 20-30% inhibition Rattus norvegicus
HgCl2 0.5 mM, complete inhibition Rattus norvegicus
KI 300 mM, 30% inhibition Rattus norvegicus
MnCl2 10 mM, 18-25%; 2.5-5 mM, 40% inhibition of enzymne from neonatal liver Rattus norvegicus
NEM 2 mM, 12% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 2.5-5 mM, stimulates 160%, enzyme from adult liver Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-2-monoacylglycerol Rattus norvegicus the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively CoA + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver adult and neonatal, enhanced expression in diabetes Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-2-monoacylglycerol the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively Rattus norvegicus CoA + diacylglycerol
-
 ?
palmitoyl-CoA + sn-2-monooleoylglycerol
-
 Rattus norvegicus CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
51
-
 after microsomes from adult liver are incubated for 13 min, they retain 44% of the control activity. After 13.5 min of heating, neonatal liver microsomes retain 90% of the control activity Rattus norvegicus
56
-
 after microsomes from adult liver are incubated for 13 min, they retain 7% of the control activity. After 13.5 min of heating, neonatal liver microsomes retain 57% of the control activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Rattus norvegicus