BRENDA - Enzyme Database
show all sequences of 2.3.1.22

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

Yen, C.L.E.; Stone, S.J.; Cases, S.; Zhou, P.; Farese, R.V., Jr.; Proc. Natl. Acad. Sci. USA 99, 8512-8517 (2002) View publication on PubMedView publication on EuropePMC

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression of MGAT1 cDNA in Spodoptera frugiperda cells
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33000
-
x * 33000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acyl-CoA + sn-2-monoacylglycerol
Mus musculus
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
CoA + diacylglycerol
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
Q91ZV4
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brown adipose tissue
MGAT1
Mus musculus
-
kidney
-
Mus musculus
-
liver
MGAT1
Mus musculus
-
stomach
-
Mus musculus
-
white adipose tissue
MGAT1
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
acyl-CoA + sn-2-monoacylglycerol
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
486605
Mus musculus
CoA + diacylglycerol
-
-
-
?
arachidonoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-arachidonoyl-2-oleoylglycerol
-
-
-
?
arachidoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-arachidoyl-2-oleoylglycerol
-
-
-
?
lauroyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-lauroyl-2-oleoylglycerol
-
-
-
?
linoleoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-linoleoyl-2-oleoylglycerol
-
-
-
?
n-octanoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-octanoyl-2-oleoylglycerol
-
-
-
?
oleoyl-CoA + sn-1-monooleoylglycerol
-
486605
Mus musculus
CoA + sn-1,3-dioleoylglycerol
-
486605
Mus musculus
?
oleoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + sn-1,2(2,3)-dioleoylglycerol
-
486605
Mus musculus
?
oleoyl-CoA + sn-3-monostearoylglycerol
-
486605
Mus musculus
CoA + 1-oleoyl-3-stearoylglycerol
-
486605
Mus musculus
?
palmitoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
?
stearoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-stearoyl-2-oleolyglycerol
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 33000, SDS-PAGE
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of MGAT1 cDNA in Spodoptera frugiperda cells
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33000
-
x * 33000, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
acyl-CoA + sn-2-monoacylglycerol
Mus musculus
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
CoA + diacylglycerol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brown adipose tissue
MGAT1
Mus musculus
-
kidney
-
Mus musculus
-
liver
MGAT1
Mus musculus
-
stomach
-
Mus musculus
-
white adipose tissue
MGAT1
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
acyl-CoA + sn-2-monoacylglycerol
in the intestine the enzyme plays a major role in the absorption of dietary fat because resynthesis of triacylglycerol is required for the assembly of lipoproteins that transport absorbed fat to other tissues
486605
Mus musculus
CoA + diacylglycerol
-
-
-
?
arachidonoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-arachidonoyl-2-oleoylglycerol
-
-
-
?
arachidoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-arachidoyl-2-oleoylglycerol
-
-
-
?
lauroyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-lauroyl-2-oleoylglycerol
-
-
-
?
linoleoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-linoleoyl-2-oleoylglycerol
-
-
-
?
n-octanoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-octanoyl-2-oleoylglycerol
-
-
-
?
oleoyl-CoA + sn-1-monooleoylglycerol
-
486605
Mus musculus
CoA + sn-1,3-dioleoylglycerol
-
486605
Mus musculus
?
oleoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + sn-1,2(2,3)-dioleoylglycerol
-
486605
Mus musculus
?
oleoyl-CoA + sn-3-monostearoylglycerol
-
486605
Mus musculus
CoA + 1-oleoyl-3-stearoylglycerol
-
486605
Mus musculus
?
palmitoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
-
-
?
stearoyl-CoA + sn-2-monooleoylglycerol
-
486605
Mus musculus
CoA + 1-stearoyl-2-oleolyglycerol
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 33000, SDS-PAGE
Mus musculus
Other publictions for EC 2.3.1.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
756729
Mochida
Inhibition of MGAT2 modulates ...
Homo sapiens, Mus musculus
FEBS Open Bio
10
316-326
2020
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
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2
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2
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2
2
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
757379
Lutkewitte
Hepatic monoacylglycerol acyl ...
Mus musculus
J. Lipid Res.
60
528-538
2019
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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-
1
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1
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1
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-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
757377
Liss
Metabolic importance of adipo ...
Mus musculus, Homo sapiens
J. Lipid Res.
59
1630-1639
2018
-
2
-
-
-
-
-
-
-
-
-
-
-
7
-
-
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-
2
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4
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2
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2
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-
-
-
-
-
-
-
-
2
1
1
2
-
-
757403
Devasthale
Monoacylglycerol acyltransfer ...
Homo sapiens, Mus musculus
J. Med. Chem.
61
9879-9888
2018
-
-
-
-
-
-
31
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
30
-
-
-
-
-
-
-
30
31
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
755776
Qi
Metabolic tracing of monoacyl ...
Homo sapiens
Anal. Biochem.
524
68-75
2017
-
1
1
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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-
-
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-
1
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1
1
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-
1
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756283
Lee
Monoacylglycerol O-acyltransf ...
Mus musculus
BMB Rep.
50
367-372
2017
-
-
-
-
1
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
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-
1
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1
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3
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-
-
-
-
-
-
-
-
1
1
-
-
-
757374
Ma
Synthesis of neutral ether li ...
Homo sapiens
J. Lipid Res.
58
1091-1099
2017
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
8
-
4
-
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-
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-
2
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-
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-
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-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
757542
Li
Metabolism of sn-1(3)-monoacy ...
Salmo trutta
Lipids
52
61-71
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
2
-
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-
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-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
758472
Adachi
Discovery of human intestinal ...
Homo sapiens
SLAS Discov.
22
360-365
2017
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
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-
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-
-
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-
1
-
1
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-
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1
1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756081
McFie
Membrane topology of human mo ...
Homo sapiens
Biochim. Biophys. Acta
1861
1192-1204
2016
-
-
1
-
6
-
2
-
3
-
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6
-
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-
-
1
-
-
1
-
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-
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1
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6
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2
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3
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1
-
-
1
-
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-
-
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-
756664
Adachi
Pharmacological characterizat ...
Homo sapiens, Mus musculus
Eur. J. Pharmacol.
791
569-577
2016
-
-
-
-
-
-
10
-
-
-
-
-
-
10
-
-
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-
-
2
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-
2
-
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-
10
-
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-
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-
10
10
-
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2
-
-
2
-
-
-
-
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-
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-
-
-
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-
-
-
-
735610
Yu
Monoacylglycerol O-acyltransfe ...
Homo sapiens
Biochem. Biophys. Res. Commun.
460
715-720
2015
-
-
1
-
1
-
-
-
2
-
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12
-
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-
4
-
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1
-
4
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1
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1
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2
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-
4
-
-
1
-
-
-
-
-
-
-
-
-
1
4
4
1
-
-
736458
Jin
Diacylglycerol acyltransferase ...
Homo sapiens
J. Biol. Chem.
289
28237-28248
2014
-
-
1
-
-
-
-
-
1
1
3
1
-
3
-
-
-
-
-
1
-
-
2
1
2
1
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-
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1
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1
-
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-
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-
1
1
3
1
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-
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-
1
-
-
2
1
1
-
-
-
1
-
-
-
-
3
3
-
-
-
735755
Barlind
Identification and design of a ...
Homo sapiens
Bioorg. Med. Chem. Lett.
23
2721-2726
2013
-
2
-
-
-
-
26
-
1
-
-
-
-
1
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-
2
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-
2
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1
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2
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1
26
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1
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2
-
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-
-
-
-
-
-
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1
1
-
-
-
736602
Gao
Intestine-specific expression ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
J. Lipid Res.
54
1644-1652
2013
-
-
2
-
2
-
-
-
-
-
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3
-
11
-
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2
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3
-
2
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2
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2
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3
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2
-
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3
-
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-
-
-
-
-
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-
3
3
-
-
-
720021
Parthibane
Oleosin is bifunctional enzyme ...
Arachis hypogaea
J. Biol. Chem.
287
1946-1954
2012
-
-
-
-
1
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1
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8
-
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1
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-
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2
-
2
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1
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1
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1
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1
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2
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
720180
Hall
Evidence for regulated monoacy ...
Homo sapiens
J. Lipid Res.
53
990-999
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
3
-
6
3
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
3
-
-
-
3
-
-
-
2
1
1
2
-
-
720755
Vijayaraj
A bifunctional enzyme that has ...
Arachis hypogaea
Plant Physiol.
160
667-683
2012
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
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-
-
-
-
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3
-
1
1
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1
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-
-
-
-
-
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2
-
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-
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-
-
-
-
-
-
-
3
-
1
-
-
-
-
1
-
-
-
1
1
-
-
-
720860
Petrie
Recruiting a new substrate for ...
Arabidopsis thaliana, Mus musculus
PLoS ONE
7
e35214
2012
-
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2
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-
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2
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2
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2
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2
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486599
Waite
Utilization of serum lipoprote ...
Rattus norvegicus
Biochim. Biophys. Acta
450
301-310
1976
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486600
Tietz
Utilization of 2-acyl-sn-glyce ...
Locusta migratoria
Biochim. Biophys. Acta
388
165-170
1975
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486602
Short
A new assay procedure for mono ...
Cavia porcellus
Biochem. J.
141
407-411
1974
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