Protein Variants | Comment | Organism |
---|---|---|
additional information | production of several dehydrogingerdione (a gingerol derivative) analogues from a recombinant Escherichia coli strain in which an artificial biosynthesis pathway for dehydrogingerdione is reconstructed that is not based on the original biosynthesis pathway of gingerol derivatives in plants. The system consists of a 4-coumarate:CoA ligase from Lithospermum erythrorhizon, a fatty acid CoA ligase from Oryza sativa, a beta-oxidation system from Saccharomyces cerevisiae, and a curcuminoid synthase from Oryza sativa | Oryza sativa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 4-coumaroyl-CoA + malonyl-CoA + H2O | Oryza sativa | - |
3 CoA + bisdemethoxycurcumin + 2 CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryza sativa | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 | curcuminoid synthase catalyzes the formation of diketide-CoA by condensing 4-coumaroyl-CoA and malonyl-CoA. The resulting diketide-CoA is hydrolyzed and converted to a beta-keto acid. Finally, curcuminoid synthase catalyzes a decarboxylative condensation of the beta-keto acid with another molecule of 4-coumaroyl-CoA, to synthesize curcuminoid | Oryza sativa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 4-coumaroyl-CoA + malonyl-CoA + H2O | - |
Oryza sativa | 3 CoA + bisdemethoxycurcumin + 2 CO2 | - |
? | |
2 4-coumaroyl-CoA + malonyl-CoA + H2O | curcuminoid synthase catalyzes the formation of diketide-CoA by condensing 4-coumaroyl-CoA and malonyl-CoA. The resulting diketide-CoA is hydrolyzed and converted to a beta-keto acid. Finally, curcuminoid synthase catalyzes a decarboxylative condensation of the beta-keto acid with another molecule of 4-coumaroyl-CoA, to synthesize curcuminoid | Oryza sativa | 3 CoA + bisdemethoxycurcumin + 2 CO2 | - |
? | |
4-coumaroyl-CoA + 3-oxodecanoyl-CoA | - |
Oryza sativa | (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)dodeca-1,4-dien-3-one + CoA + CO2 + H2O | - |
? | |
4-coumaroyl-CoA + 3-oxododecanoyl-CoA | - |
Oryza sativa | (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)tetradeca-1,4-dien-3-one + CoA + CO2 + H2O | - |
? | |
4-coumaroyl-CoA + 3-oxooctanoyl-CoA | - |
Oryza sativa | (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)deca-1,4-dien-3-one + CoA + CO2 + H2O | - |
? | |
4-coumaroyl-CoA + 3-oxotetradecanoyl-CoA | - |
Oryza sativa | (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)hexadeca-1,4-dien-3-one + CoA + CO2 + H2O | - |
? | |
additional information | the enzyme is capable of synthesizing gingerol-related compounds by condensing 4-coumaroyl-CoA with 3-oxooctanoic acid (a beta-keto acid), or with 3-oxoocarboxyl-N-acetylcysteamine thioester, a diketide-CoA analogue, in vitro. The enzyme is inactive with 3-oxoacyl derivatives of chain lengths beow C8 and above C14, overview | Oryza sativa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
curcuminoid synthase | - |
Oryza sativa |
CUS | - |
Oryza sativa |