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Literature summary for 2.3.1.21 extracted from

  • Violante, S.; Ijlst, L.; van Lenthe, H.; de Almeida, I.T.; Wanders, R.J.; Ventura, F.V.
    Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling (2010), Biochim. Biophys. Acta, 1802, 728-732.
    View publication on PubMed
Search for more literature for 2.3.1.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
trans-2-hexadecenoyl-CoA competitive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0071
-
 palmitoyl-CoA pH 7.4, 37°C Homo sapiens
0.0081
-
 trans-2-hexadecenoyl-CoA pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23786 isoform CPT2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,8-dimethylnonanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + 4,8-dimethylnonanoyl-L-carnitine
-
 ?
decanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-decanoylcarnitine
-
 ?
dodecanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-dodecanoylcarnitine
-
 ?
lauroyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-lauroylcarnitine
-
 ?
additional information isoform CPT2 is active with medium and long-chain acyl-CoA esters, whereas virtually no activity is found with short- and very long-chain acyl-CoAs or with branched-chain amino acid oxidation intermediates. Trans-2-enoyl-CoA intermediates are poor substrates, too. Isoform CPT2 is able to reverse its physiological mechanism for medium and long-chain acyl-CoAs contributing to the abnormal acylcarnitines profiles characteristic of most mitochondrial fatty acid beta-oxidation disorders Homo sapiens ?
-
 ?
additional information no substrates are: isovaleryl-CoA, isobutyryl-CoA, acetoacetyl-CoA, DL-3-hydroxybutyryl-CoA, 3-hydroxyisobutyryl-CoA, 2-methylacetoacetyl-CoA, methylcrotonyl-CoA, glutaryl-CoA, 3-hydroxy-3-methylglutaryl-CoA, 2-methylbutyryl-CoA, 2-methyl-3-hydroxybutyryl-CoA Homo sapiens ?
-
 ?
myristoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-myristoylcarnitine
-
 ?
octanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-octanoylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
trans-2-hexadecenoyl-CoA + L-carnitine
-
 Homo sapiens CoA + trans-2-hexadecenoyl-L-carnitine
-
 ?

Synonyms

Synonyms Comment Organism
CPT2
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0188
-
 trans-2-hexadecenoyl-CoA pH 7.4, 37°C Homo sapiens