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Literature summary for 2.3.1.21 extracted from

  • Price, N.T.; Jackson, V.N.; Muller, J.; Moffat, K.; Borthwick, K.L.; Orton, T.; Zammit, V.A.
    Alternative exon usage in the single carnitine palmitoyltransferase 1 (CPT 1) gene of drosophila generates functional diversity in the kinetic properties of the enzyme. Differential expression of alternatively spliced variants in drosophila tissues (2010), J. Biol. Chem., 285, 7857-7865.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA
-
 Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.104
-
 palmitoyl-CoA
-
 Drosophila melanogaster
0.406
-
 L-carnitine
-
 Drosophila melanogaster
0.52
-
 palmitoyl-CoA
-
 Drosophila melanogaster
0.59 1 L-carnitine
-
 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fat body
-
 Drosophila melanogaster
-
fat body present to a significant greater extent in flight muscle than in fat body Drosophila melanogaster
-
muscle
-
 Drosophila melanogaster
-
muscle present to a significant greater extent in flight muscle than in fat body Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-carnitine + palmitoyl-CoA
-
 Drosophila melanogaster L-palmitoylcarnitine + CoA
-
 ?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase 1 splice variant exon 6A Drosophila melanogaster
carnitine palmitoyltransferase 1 splice variant exon 6B Drosophila melanogaster

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00067
-
 malonyl-CoA KI-values: 0.00064 mM and 0.0007 mM malony-CoA (from secondary Dixon plots) Drosophila melanogaster

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00074
-
 at 0.035 mM palmitoyl-CoA Drosophila melanogaster malonyl-CoA
0.00076
-
 at 0.035 mM palmitoyl-CoA Drosophila melanogaster malonyl-CoA
0.00101
-
 at 0.07 mM palmitoyl-CoA Drosophila melanogaster malonyl-CoA
0.00232
-
 at 0.07 mM palmitoyl-CoA Drosophila melanogaster malonyl-CoA