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Literature summary for 2.3.1.21 extracted from

  • Sierra, A.Y.; Gratacos, E.; Carrasco, P.; Clotet, J.; Urena, J.; Serra, D.; Asins, G.; Hegardt, F.G.; Casals, N.
    CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity (2008), J. Biol. Chem., 283, 6878-6885.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
CPT1c cDNA is amplified and cloned into the pBlueScript vector, sequenced and subsequently cloned into pEGFP-N3, the coding regions of CPT1a and CPT1c are cloned into vector pIRES2-EGFP, chimeras between CPT1c and CPT1a are constructed Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.9
-
palmitoyl-CoA microsomes, PC-12 cell, CPT1a Rattus norvegicus
25.35
-
palmitoyl-CoA microsomes of PC-12 cells overexpressing CPT1c Rattus norvegicus
58.53
-
L-carnitine microsomes of PC-12 cells overexpressing CPT1c Rattus norvegicus
127
-
L-carnitine microsomes, PC-12 cell, CPT1a Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Rattus norvegicus 5783
-
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Rattus norvegicus
-
CoA + L-palmitoylcarnitine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomes are prepared Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
neuron
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00035
-
transfected HEK-293T cell Rattus norvegicus
0.00194
-
transfectecd PC-12 cell Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
Rattus norvegicus CoA + L-palmitoylcarnitine
-
?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase
-
Rattus norvegicus
CPT1
-
Rattus norvegicus
CPT1c
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
activity assay Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
activity assay Rattus norvegicus