Literature summary for 2.3.1.21 extracted from

Stefanovic-Racic, M.; Perdomo, G.; Mantell, B.S.; Sipula, I.J.; Brown, N.F.; ODoherty, R.M.
A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels (2008), Am. J. Physiol. Endocrinol. Metab., 294, E969-E977.

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Application

Application	Comment	Organism
pharmacology	the data represent proof in principle that a pharmacological agent that stimulates hepatic fatty acid oxidation, perhaps acting on carnitine palmitoyltransferase 1a, could provide a novel approach to treatment of nonalcoholic fatty liver disease	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant adenoviruses containing cDNAs encoding rat CPT1a and rat CPT2 are constructed	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrial outer membrane	CPT1a	Rattus norvegicus	5741	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
palmitoyl-CoA + L-carnitine	Rattus norvegicus	-	CoA + L-palmitoylcarnitine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P18886	male Sprague-Dawley rat	-
Rattus norvegicus	P32198	male Sprague-Dawley rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0006	-	hepatocytes transduced with adenovirus encoding beta-galctosidase exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period	Rattus norvegicus
0.0008	-	hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period	Rattus norvegicus
0.001	-	hepatocytes transduced with adenovirus encoding beta-galctosidase exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period	Rattus norvegicus
0.0017	-	hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-1 activity at the end of the incubation period	Rattus norvegicus
0.0019	-	hepatocytes transduced with adenovirus encoding CPT-1a exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period	Rattus norvegicus
0.0021	-	hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding beta-galctosidase, incubation with palmitate	Rattus norvegicus
0.0029	-	hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding beta-galctosidase, incubation with palmitate	Rattus norvegicus
0.0029	-	hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding CPT-2, incubation with palmitate	Rattus norvegicus
0.0033	-	hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-2, incubation with palmitate	Rattus norvegicus
0.0041	-	hepatic CPT-1 activity, rats fed standard diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate	Rattus norvegicus
0.0051	-	hepatic CPT-1 activity, rats fed high-fat diet, transduced with adenovirus encoding CPT-1a, incubation with palmitate	Rattus norvegicus
0.0063	-	hepatocytes transduced with adenovirus encoding CPT-2 exposed to exogenous palmitate, measurement of CPT-2 activity at the end of the incubation period	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoyl-CoA + L-carnitine	-	Rattus norvegicus	CoA + L-palmitoylcarnitine	-	?

Synonyms

Synonyms	Comment	Organism
carnitine O-palmitoyltransferase	-	Rattus norvegicus
carnitine palmitoyltransferase 1A	-	Rattus norvegicus
carnitine palmitoyltransferase 2	-	Rattus norvegicus
CPT	-	Rattus norvegicus
CPT1A	-	Rattus norvegicus
CPT2	-	Rattus norvegicus

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Release 2023.1 (January 2023)