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Literature summary for 2.3.1.21 extracted from
- Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity (2003), Biochem. Biophys. Res. Commun., 301, 758-763.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| mutant enzymes expressed in Pichia pastoris | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| DELTA563-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA659-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA728-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA752-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA762-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA763-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
| DELTA766-772 | activity of the mutant is similar to wild-type enzyme | Homo sapiens |
| DELTA769-772 | activity of the mutant is similar to wild-type enzyme | Homo sapiens |
| L264A | 60.4% of the wild-type activity | Homo sapiens |
| L764R | 16.3% of the wild-type activity | Homo sapiens |
| L764V | as active as the wild-type enzyme | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0448 | - |
palmitoyl-CoA | mutant enzyme L764R | Homo sapiens |  |
| 0.0466 | - |
palmitoyl-CoA | wild-type enzyme | Homo sapiens | |
| 0.679 | - |
L-carnitine | wild-type enzyme | Homo sapiens | |
| 1.588 | - |
L-carnitine | mutant enzyme L764R | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92523 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carnitine palmitoyltransferase I | - |
Homo sapiens |
| M-CPTI | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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