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Literature summary for 2.3.1.21 extracted from

  • Eaton, S.; Fukumoto, K.; Paladio Duran, N.; Pierro, A.; Spitz, L.; Quant, P.A.; Bartlett, K.
    Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux (2001), Biochem. Soc. Trans., 29, 245-250.
    View publication on PubMed
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA inhibits CPT I not CPT II; isoforms L-CPT I and M-CPT I Homo sapiens
malonyl-CoA differences in sensitivity of hepatic and heart enzyme; inhibits CPT I not CPT II; isoforms L-CPT I and M-CPT I Rattus norvegicus
additional information physiological role of malonyl-CoA in the heart Homo sapiens
additional information physiological role of malonyl-CoA in the heart Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information forward reaction by CPT I at outer mitochondrial membrane, transport of acylcarnitine through mitochondrial membrane, reverse reaction at inner face of inner membrane by CPT II, overview Homo sapiens
-
-
additional information forward reaction by CPT I at outer mitochondrial membrane, transport of acylcarnitine through mitochondrial membrane, reverse reaction at inner face of inner membrane by CPT II, overview Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
82000
-
 x * 82000, M-CPT I, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Homo sapiens CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control CoA + L-acylcarnitine
-
 r
acyl-CoA + L-carnitine Rattus norvegicus CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control CoA + L-acylcarnitine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 2 isoforms L-CPT I and M-CPT I
-
Rattus norvegicus
-
 2 isoforms of CPT I in heart mitochondria, liver L-CPT I, skeletal muscle M-CPT I
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
heart
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
skeletal muscle
-
 Homo sapiens
-
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 r
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 r
acyl-CoA + L-carnitine CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control Homo sapiens CoA + L-acylcarnitine
-
 r
acyl-CoA + L-carnitine CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control Rattus norvegicus CoA + L-acylcarnitine
-
 r

Subunits

Subunits Comment Organism
? x * 82000, M-CPT I, SDS-PAGE Rattus norvegicus