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Literature summary for 2.3.1.21 extracted from

  • Hertel, K.; Gellerich, F.N.; Hein, W.; Zierz, S.
    Kinetic investigation of carnitine palmitoyltransferases in homogenates of human skeletal muscle using L-amino-carnitine and malonyl-CoA (1999), Adv. Exp. Med. Biol., 466, 87-93.
    View publication on PubMed
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
L-aminocarnitine inhibition of CPT II not CPT I Homo sapiens
malonyl-CoA CPT I; CPT II not inhibited; regulatory role in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 CPT II
-
Homo sapiens
-
 CPT I
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle CPT II Homo sapiens
-
skeletal muscle CPT I Homo sapiens
-
skeletal muscle Musculus vastus lateralis Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 CPT I and II activities in muscle biopsis Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 r
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0035
-
 L-aminocarnitine CPT II Homo sapiens