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Literature summary for 2.3.1.21 extracted from
- Purification and properties of peroxisomal carnitine palmitoyltransferase in chick embryo liver (1987), Biochim. Biophys. Acta, 924, 530-542.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Trypsin | peroxisomal and mitochondrial isozymes | Gallus gallus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | overview: Km values for several acyl-CoA and acyl-carnitine substrates, both reaction directions, peroxisomal and mitochondrial isozyme | Gallus gallus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Gallus gallus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
1 * 64000, peroxisomes, SDS-PAGE | Gallus gallus |
| 66000 | - |
peroxisomes, gel filtration | Gallus gallus |
| 69000 | - |
4 * 69000, mitochondria | Gallus gallus |
| 260000 | - |
mitochondria, gel filtration | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Gallus gallus | - |
CoA + L-acylcarnitine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
embryo | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| peroxisomal | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| 4.65 | - |
purified mitochondrial enzyme | Gallus gallus |
| 13.2 | - |
purified peroxisomal enzyme | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | - |
Gallus gallus | CoA + L-acylcarnitine | - |
? | |
| acyl-CoA + L-carnitine | substrate specificity | Gallus gallus | CoA + L-acylcarnitine | reverse reaction: acyl-CoA substrates are C4 to C18 acylcarnitines | r | |
| acyl-CoA + L-carnitine | C4 to C18 acyl-CoAs | Gallus gallus | CoA + L-acylcarnitine | reverse reaction: acyl-CoA substrates are C4 to C18 acylcarnitines | r | |
| palmitoyl-CoA + L-carnitine | - |
Gallus gallus | CoA + L-palmitoylcarnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 64000, peroxisomes, SDS-PAGE | Gallus gallus |
| tetramer | 4 * 69000, mitochondria | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | mitochondrial | Gallus gallus |
| 8.5 | - |
peroxisomal | Gallus gallus |
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