Literature summary for 2.3.1.202 extracted from

Ud-Din, A.I.; Liu, Y.C.; Roujeinikova, A.
Crystal structure of Helicobacter pylori pseudaminic acid biosynthesis N-acetyltransferase PseH: implications for substrate specificity and catalysis (2015), PLoS ONE, 10, e0115634.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with cofactor acetyl-CoA, to 2.3 A resolution. PseH is a homodimer in the crystal, each subunit of which has a central twisted beta-sheet flanked by five alpha-helices. The cofactor-binding site is located between the splayed strands beta4 and beta5. The catalytic mechanism involves direct acetyl transfer from AcCoA without an acetylated enzyme intermediate. Modeling of the Michaelis complex suggests that the nucleotide- and 4-amino-4,6-dideoxy-beta-L-AltNAc-binding pockets form extensive interactions with the substrate and are thus the most significant determinants of substrate specificity. A hydrophobic pocket accommodating the 6'-methyl group of the altrose dictates preference to the methyl over the hydroxyl group	Helicobacter pylori

Crystallization (Comment)

Organism

in complex with cofactor acetyl-CoA, to 2.3 A resolution. PseH is a homodimer in the crystal, each subunit of which has a central twisted beta-sheet flanked by five alpha-helices. The cofactor-binding site is located between the splayed strands beta4 and beta5. The catalytic mechanism involves direct acetyl transfer from AcCoA without an acetylated enzyme intermediate. Modeling of the Michaelis complex suggests that the nucleotide- and 4-amino-4,6-dideoxy-beta-L-AltNAc-binding pockets form extensive interactions with the substrate and are thus the most significant determinants of substrate specificity. A hydrophobic pocket accommodating the 6'-methyl group of the altrose dictates preference to the methyl over the hydroxyl group

Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	O25094	-	-
Helicobacter pylori ATCC 700392	O25094	-	-

Synonyms

Synonyms	Comment	Organism
PsEH	-	Helicobacter pylori

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Release 2023.1 (January 2023)