Literature summary for 2.3.1.201 extracted from

Ma, G.; Cheng, N.; Su, H.; Liu, Y.
Exploring the substrate-assisted acetylation mechanism by UDP-linked sugar N-acetyltransferase from QM/MM calculations: The role of residue Asn84 and the effects of starting geometries (2015), RSC Adv., 5, 7781-7788.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
QM/MM calculations reveal two sequential steps in the catalyzation process. The nucleophilic attack of the C3-amino group of the substrate on the carbonyl carbon of acetyl-CoA occurs in concert with the departure of CoA from acetyl-CoA, generating a negatively charged CoA and a positively charged intermediate. Subsequently, the sulfur anion of CoA accepts the proton of the positively charged intermediate to yield the final product. Asn84 is important for promoting the catalysis by forming a hydrogen bond with the C3-amino group to position the lone pair of the electrons of the C3-amino group in an ideal orientation for nucleophilic attack and stabilize the transition states and intermediate	Bordetella petrii

Crystallization (Comment)

Organism

QM/MM calculations reveal two sequential steps in the catalyzation process. The nucleophilic attack of the C3-amino group of the substrate on the carbonyl carbon of acetyl-CoA occurs in concert with the departure of CoA from acetyl-CoA, generating a negatively charged CoA and a positively charged intermediate. Subsequently, the sulfur anion of CoA accepts the proton of the positively charged intermediate to yield the final product. Asn84 is important for promoting the catalysis by forming a hydrogen bond with the C3-amino group to position the lone pair of the electrons of the C3-amino group in an ideal orientation for nucleophilic attack and stabilize the transition states and intermediate

Bordetella petrii

Organism

Organism	UniProt	Comment	Textmining
Bordetella petrii	A9IH93	-	-
Bordetella petrii DSM 12804	A9IH93	-	-

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Release 2023.1 (January 2023)