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Literature summary for 2.3.1.198 extracted from
- Quantitative analysis of glycerol in dicarboxylic acid-rich cutins provides insights into Arabidopsis cutin structure (2016), Phytochemistry, 130, 159-169 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene gpat4 | Arabidopsis thaliana |
| gene gpat8 | Arabidopsis thaliana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | glycerol content is strongly reduced in both stem and leaf cutin from all Arabidopsis thaliana mutants analyzed (gpat4/gpat8). Knocking out of these genes individually or as a pair (gpat4/gpat8) leads to large reductions in Arabidopsis thaliana cutin monomer loads, especially in the major monomer octadeca-6,9-diene-1,18-dioate (C18:2 DCA) | Arabidopsis thaliana |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + sn-glycerol 3-phosphate | Arabidopsis thaliana | - |
CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? |  |
| acyl-CoA + sn-glycerol 3-phosphate | Arabidopsis thaliana Col-0 | - |
CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Arabidopsis thaliana | Q5XF03 | - |
- |
| Arabidopsis thaliana Col-0 | - |
- |
- |
| Arabidopsis thaliana Col-0 | Q5XF03 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Arabidopsis thaliana | - |
| stem | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + sn-glycerol 3-phosphate | - |
Arabidopsis thaliana | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | isozyme GPAT4 acylates glycerol-3-phosphate at the sn-2 position | Arabidopsis thaliana | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | isozyme GPAT8 acylates glycerol-3-phosphate at the sn-2 position | Arabidopsis thaliana | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | - |
Arabidopsis thaliana Col-0 | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | isozyme GPAT4 acylates glycerol-3-phosphate at the sn-2 position | Arabidopsis thaliana Col-0 | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
| acyl-CoA + sn-glycerol 3-phosphate | isozyme GPAT8 acylates glycerol-3-phosphate at the sn-2 position | Arabidopsis thaliana Col-0 | CoA + 2-acyl-sn-glycerol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycerol-3-phosphate 2-O-acyltransferases | - |
Arabidopsis thaliana |
| GPAT4 | - |
Arabidopsis thaliana |
| GPAT8 | - |
Arabidopsis thaliana |
| sn-2-GPAT | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | glycerol content is strongly reduced in both stem and leaf cutin from all Arabidopsis thaliana mutants analyzed (gpat4/gpat8). Knocking out any of these genes individually, or as a pair (gpat4/gpat8), leads to large reductions in Arabidopsis thaliana cutin monomer loads, especially in the major monomer octadeca-6,9-diene-1,18-dioate (C18:2 DCA). sn-2-GPATs play pivotal roles in providing glycerol as a structural monomer for cutin through regiospecific sn-2 acylation of glycerol-3-phosphate. The double-knockout gpat4/gpat8 has an overall 60-70% reduction of aliphatic monomers in stem and leaf cutin, and the most pronounced decrease occurs in its major monomer, C18:2 dicarboxylic acyl-CoA (DCA) | Arabidopsis thaliana |
| metabolism | isozymes GPAT4 and GPAT8 are glycerol-3-phosphate 2-O acyltransferases that catalyze the first step in leaf and stem cutin acylglycerol assembly | Arabidopsis thaliana |
| physiological function | glycerol-3-phosphate 2-O-acyltransferases (sn-2-GPATs) are essential for cutin biosynthesis and involved in cutin polymerization, cutin structures and compositions in plant tissues, detailed overview | Arabidopsis thaliana |
| physiological function | the enzyme is involved in cutin polymerization, cutin structures and compositions in plant tissues, detailed overview | Arabidopsis thaliana |
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