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Literature summary for 2.3.1.191 extracted from

  • Ma, X.; Prathapam, R.; Wartchow, C.; Chie-Leon, B.; Ho, C.M.; De Vicente, J.; Han, W.; Li, M.; Lu, Y.; Ramurthy, S.; Shia, S.; Steffek, M.; Uehara, T.
    Structural and biological basis of small molecule inhibition of Escherichia coli LpxD acyltransferase essential for lipopolysaccharide biosynthesis (2019), ACS Infect. Dis., 6, 1480-1489 .
    View publication on PubMed
Search for more literature for 2.3.1.191

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in complex with 4-(2-chlorophenyl)-3-hydroxy-7,7-dimethyl-2-phenyl-7,8-dihydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one. Enzyme in complex with 3-hydroxy-7,7-dimethyl-2-phenyl-4-(thiophen-2-yl)-7,8-dihydro-2H-pyrazolo[3,4-b]-quinolin-5(6H)-one Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
4-(2-chlorophenyl)-3-hydroxy-7,7-dimethyl-2-phenyl-7,8-dihydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one
-
 Escherichia coli
TNLYMLPKWDIP-NH2 i.e. peptide RJPXD33 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli Q0P6M7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Synonyms

Synonyms Comment Organism
LpxD
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism the enzyme is involved in lipid A biosynthesis in Gram-negative bacteria Escherichia coli