Cloned (Comment) | Organism |
---|---|
gene mdcA, encoded in the malonate decarboxylase operon mdc, genetic organization | Klebsiella pneumoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60800 | - |
x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE | Klebsiella pneumoniae |
61200 | - |
x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE | Malonomonas rubra |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonate + acetyl-[acyl-carrier protein] | Klebsiella pneumoniae | - |
acetate + malonyl-[acyl-carrier protein] | - |
? | |
malonate + acetyl-[acyl-carrier protein] | Malonomonas rubra | - |
acetate + malonyl-[acyl-carrier protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | - |
gene mdcA, encoded in the malonate decarboxylase operon mdc | - |
Malonomonas rubra | - |
gene madA, encoded in the malonate decarboxylase operon mad | - |
Purification (Comment) | Organism |
---|---|
isolated soluble native transferase component of the malonate decarboxylase | Malonomonas rubra |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
malonate + acetyl-[acyl-carrier protein] | - |
Klebsiella pneumoniae | acetate + malonyl-[acyl-carrier protein] | - |
? | |
malonate + acetyl-[acyl-carrier protein] | - |
Malonomonas rubra | acetate + malonyl-[acyl-carrier protein] | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE | Klebsiella pneumoniae |
? | x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE | Malonomonas rubra |
Synonyms | Comment | Organism |
---|---|---|
acetyl-S-ACP:malonate ACP transferase | - |
Klebsiella pneumoniae |
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase | - |
Malonomonas rubra |
MadA | - |
Malonomonas rubra |
MdcA | - |
Klebsiella pneumoniae |
General Information | Comment | Organism |
---|---|---|
metabolism | to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview | Klebsiella pneumoniae |
metabolism | to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview | Malonomonas rubra |
additional information | the acetyl-S-ACP:malonate ACP transferase is a component of the malonate decarboxylase complex | Klebsiella pneumoniae |
additional information | the acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase is a component of the malonate decarboxylase complex | Malonomonas rubra |