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Literature summary for 2.3.1.181 extracted from

  • Christensen, Q.H.; Cronan, J.E.
    Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases (2010), Biochemistry, 49, 10024-10036.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Bacillus subtilis

Protein Variants

Protein Variants Comment Organism
C150A loss of the overall catalytic activity and an inability to form the acyl-enzyme intermediate Bacillus subtilis
C150S loss of the overall catalytic activity and an inability to form the acyl-enzyme intermediate Bacillus subtilis
K165A mutant has weakened catalytic ability Bacillus subtilis
K165R mutant remains active Bacillus subtilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
14000
-
gel filtration Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
octanoyl-[acyl-carrier protein] + a protein Bacillus subtilis
-
a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
octanoyl-[acyl-carrier protein] + a protein
-
Bacillus subtilis a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
-
?
octanoyl-[acyl-carrier protein] + a protein the transfer of the octanoyl group from octanoyl-ACP to Bacillus subtilis GcvH occurs in a LipM-dependent manner. The LipM reaction proceeds through a thioester-linked acyl enzyme intermediate. The LipM active site nucleophile is identified as C150 Bacillus subtilis a protein N6-(octanoyl)lysine + an [acyl-carrier protein]
-
?

Subunits

Subunits Comment Organism
monomer 1 * 14000, SDS-PAGE Bacillus subtilis

Synonyms

Synonyms Comment Organism
LipM
-
Bacillus subtilis
octanoyltransferase LipM
-
Bacillus subtilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Bacillus subtilis