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Literature summary for 2.3.1.180 extracted from

  • Lee, J.Y.; Jeong, K.W.; Shin, S.; Lee, J.U.; Kim, Y.
    Antimicrobial natural products as beta-ketoacyl-acyl carrier protein synthase III inhibitors (2009), Bioorg. Med. Chem., 17, 5408-5413.
    View publication on PubMed
Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment) Organism
gene fabH, expression in Escherichia coli strain BL21(DE3) Escherichia coli K-12

Inhibitors

Inhibitors Comment Organism Structure
3,6-dihydroxyflavone i.e. YKAF01 Escherichia coli K-12
3-(4-hydroxyphenyl)-1-(2,4,6-tri-hydroxyphenyl)propan-1-one i.e. YKAF04, or 4,2',4',6'-tetrahydroxychalcone, or phloretin Escherichia coli K-12
additional information inhibitor structure analysis by NMR, binding analysis, and antibacterial activities, overview Escherichia coli K-12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + malonyl-[acyl-carrier protein] Escherichia coli K-12
-
 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli K-12
-
 gene fabH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Escherichia coli K-12 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Escherichia coli K-12
KAS III
-
 Escherichia coli K-12

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Escherichia coli K-12