Any feedback?
Literature summary for 2.3.1.180 extracted from
- In-vitro evidence for feed-back regulation of beta-ketoacyl-acyl carrier protein synthase III in medium-chain fatty acid biosynthesis (1996), Planta, 198, 271-278.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| butyryl-[acyl-carrier protein] | feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism | Cuphea lanceolata |  |
| decanoyl-CoA | IC50 is 0.004 mM | Cuphea lanceolata | |
| decanoyl-[acyl-carrier protein] | reversible, noncompetitive inhibition versus malonyl-[acyl-carrier-protein] and uncompetitive versus acetyl-CoA, IC50 is 0.00045 mM | Cuphea lanceolata | |
| hexanoyl-[acyl-carrier protein] | feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism | Cuphea lanceolata | |
| octanoyl-[acyl-carrier protein] | feed-back inhibition of the enzyme via decrease in affinity for acetyl-CoA, inhibition mechanism | Cuphea lanceolata | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Cuphea lanceolata |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + malonyl-[acyl-carrier protein] | Cuphea lanceolata | first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cuphea lanceolata | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Cuphea lanceolata | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Cuphea lanceolata | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
r | |
| acetyl-CoA + malonyl-[acyl-carrier protein] | first condensing step in fatty acid synthase reaction, the enzyme is feedback regulated in biosynthesis of medium chain fatty acids | Cuphea lanceolata | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-ketoacyl-acyl carrier protein synthase III | - |
Cuphea lanceolata |
| KAS III | - |
Cuphea lanceolata |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Cuphea lanceolata |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Cuphea lanceolata |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00045 | - |
reversible, noncompetitive inhibition versus malonyl-[acyl-carrier-protein] and uncompetitive versus acetyl-CoA, IC50 is 0.00045 mM | Cuphea lanceolata | decanoyl-[acyl-carrier protein] | |
| 0.004 | - |
IC50 is 0.004 mM | Cuphea lanceolata | decanoyl-CoA | |
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Release 2023.1 (January 2023)
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