Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for development of antibiotics | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
purified FabH as apoenzyme or with bound acetyl-CoA, structure and reaction mechanism modeling | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | the enzyme is a key catalyst of fatty acid biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | catalytic residues are Cys112, His244, and Asn274, catalytic reaction mechanism includes acetylation of Cys112 in the primer binding pocket, structure and reaction mechanism modeling | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is a key catalyst of fatty acid biosynthesis | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme shows a condensing enzyme fold | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-acyl carrier protein synthase III | - |
Escherichia coli |
FabH | - |
Escherichia coli |