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Literature summary for 2.3.1.180 extracted from
- Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH) (2005), J. Bacteriol., 187, 3795-3799.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutagenic replacement of the chromosomal endogenous enzyme by a plasmid-encoded Escherichia coli enzyme leads to a highly altered fatty acid profile in Streptomyces coelicolor, while plasmid-encoded expression of the Streptomyces glaucescens enzyme alters the fatty acid profile only slightly, overview | Streptomyces coelicolor |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + malonyl-[acyl-carrier protein] | Streptomyces coelicolor | the enzyme initiates the fatty acid biosynthesis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |  |
| additional information | Streptomyces coelicolor | fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces coelicolor | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Streptomyces coelicolor | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| acetyl-CoA + malonyl-[acyl-carrier protein] | the enzyme initiates the fatty acid biosynthesis | Streptomyces coelicolor | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| additional information | substrate specificity | Streptomyces coelicolor | ? | - |
? | |
| additional information | fatty acid composition of wild-type and mutant strains, the latter expressing plasmid-encoded Escherichia coli or Streptomyces glaucescens enzymes, overview | Streptomyces coelicolor | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-ketoacyl acyl carrier protein synthase III | - |
Streptomyces coelicolor |
| FabH | - |
Streptomyces coelicolor |
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