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Literature summary for 2.3.1.180 extracted from
- Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis (1999), Biochemistry, 38, 9752-9757.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Streptomyces lividans | Streptomyces peucetius |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37189 | - |
1 * 37189, recombinant enzyme, mass spectrometry | Streptomyces peucetius |
| 38000 | - |
gel filtration, recombinant enzyme | Streptomyces peucetius |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| propionyl-CoA + malonyl-[acyl-carrier protein] | Streptomyces peucetius | the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis | 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces peucetius | - |
gene dpsC | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme from Streptomyces lividans by ammonium sulfate fractionation, gel filtration, ion exchange and hydrophobic interaction chromatography | Streptomyces peucetius |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no activity with acetyl-CoA, malonyl-CoA, and 2-methylmalonyl-CoA as primer for elongation of fatty acids, the enzyme shows also acyl-CoA:ACP transacylase activity for transfer of propionate to ACP | Streptomyces peucetius | ? | - |
? | |
| propionyl-CoA + malonyl-[acyl-carrier protein] | the enzyme specifies the propionate-starter unit for type II polyketide biosynthesis | Streptomyces peucetius | 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| propionyl-CoA + malonyl-[acyl-carrier protein] | intermediate binding of propionyl to the enzyme at Ser118 | Streptomyces peucetius | 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 37189, recombinant enzyme, mass spectrometry | Streptomyces peucetius |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-ketoacyl:acyl carrier protein synthase III | - |
Streptomyces peucetius |
| DpsC | - |
Streptomyces peucetius |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Streptomyces peucetius |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Streptomyces peucetius |
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Release 2023.1 (January 2023)
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